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Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists

✍ Scribed by Roland Lang; Alexandra Berger; Radmila Santic; Roland Geisberger; Anton Hermann; Herbert Herzog; Barbara Kofler


Book ID
113824300
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
157 KB
Volume
39
Category
Article
ISSN
0143-4179

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## Abstract A set of racemic spirocyclic quinuclidinyl‐Δ^2^‐isoxazoline derivatives was synthesized using a 1,3‐dipolar cycloaddition‐based approach. Target compounds were assayed for binding affinity toward rat neuronal homomeric (α7) and heteromeric (α4β2) nicotinic acetylcholine receptors. Δ^2^‐