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Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium

✍ Scribed by M. Bardou; J Cortijo; C. Loustalot; S. Taylor; A. Perales-Marín; F.J. Mercier; M. Dumas; C. Deneux-Tharaux; R. Frydman; E.J. Morcillo; C. Advenier


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
69 KB
Volume
360
Category
Article
ISSN
0028-1298

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## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by