Pharmacological activities of branched-chain amino acids: specificity of tissue and signal transduction
โ Scribed by Shinobu Nishitani; Chiori Ijichi; Kenji Takehana; Shoji Fujitani; Ichiro Sonaka
- Book ID
- 116287527
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 101 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0006-291X
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๐ SIMILAR VOLUMES
The synthesis of brain glutamate requires an amino group donor that is efficiently transported into the brain and that is readily transaminated. The branchedchain amino acids (BCAA), particularly leucine, play this important role. The uptake of leucine across the blood-brain barrier is faster than a
We investigated the effects of the branched-chain amino acids-valine, leucine and isoleucine-or their keto analogs, the branched-chain keto acids-a-ketoisovaleric acid, a-ketoisocaproic acid and a-keto-d-methylvaleric acid-n protein synthesis and secretion by monolayers of rabbit hepatocytes incubat