Pharmacologic evaluation of various metabolites and analogs of valproic acid: Teratogenic potencies in mice
β Scribed by NAU, H
- Book ID
- 122461478
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 650 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0272-0590
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## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a
The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. Treatment of pregnant dams (600 mg/kg sodium valproate in distilled water, i.p.) during