Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation
β Scribed by Yu Chul Kim; Ae Kyung Lee; Joo Hyun Lee; Inchul Lee; Duk Chul Lee; So Hee Kim; Sang Geon Kim; Myung Gull Lee
- Book ID
- 113591520
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 269 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0928-0987
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## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYPβmediated mechanisms underlying ageβdependent differences in susceptibility to toxicity. We evaluated CYP expressi