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Pharmacokinetics of theophylline before and after nephrectomy in dogs

โœ Scribed by Richard E. Brashear; Peter Veng-Pedersen; Michael D. Karol

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
441 KB
Volume
10
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The role of the kidneys in the elimination of theophylline was directly assessed using nephrectomized dogs. Data was analyzed by two different pharmacokinetic approaches. Analysis indicated that a given dosage regimen produced significantly different serum concentrations before and after nephrectomy. Model independent pharmacokinetic analysis failed to show a significant difference in parameters. A model dependent approach, using a nonlinear regression analysis employing a linear two-compartment model, demonstrated that the differences observed could be accounted for by a change in the first order elimination kinetics.

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