𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of stobadin and of the sum of its metabolites in rats during repeated administration

✍ Scribed by Zoltán Kállay; Ladislav Šoltés; Tomáš Trnovec

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
225 KB
Volume
12
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Stobadin dihydrochloride was administered p.0. to rats at a dose of lmg kg-' once daily for 25 consecutive days. The peak and trough concentrations of the sum of stobadin metabolites, determined from Days 6 1 6 of treatment, demonstrated a steady-state. The mean daily excretion of 'H-radioactivity during this period was 43 per cent and 52 per cent of the administered dose into urine and faeces, respectively. The terminal half-life of stobadin in plasma following a 25-day chronic treatment was 78.3 min, which was shorter than the value of 95.3 min, determined in a single dose experiment. The data indicate that no accumulation of stobadin and of its labelled metabolites occurs in the course of repeated administration of 'H-stobadin.

📜 SIMILAR VOLUMES

Pharmacokinetics of desethylamiodarone i
Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone
✍ Anooshirvan Shayeganpour; Dalia A. Hamdy; Dion R. Brocks 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i

Stereoselective pharmacokinetics of desb
Stereoselective pharmacokinetics of desbutylhalofantrine, a metabolite of halofantrine, in the rat after administration of the racemic metabolite or parent drug
✍ Dion R. Brocks 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB

## Abstract The main objective of this study was to determine the pharmacokinetics of the enantiomers of desbutylhalofantrine (DHF), a metabolite of halofantrine (HF), in the rat. Rats received either intravenous (2 mg/kg) or oral (7 mg/kg) (±)‐DHF HCl, or (±)‐HF HCl intravenously (3 mg/kg). Enanti

Pharmacokinetics of α-dihydroergocriptin
Pharmacokinetics of α-dihydroergocriptine in rats after single intravenous and single and repeated oral administrations
✍ G. Coppi; S. Silingardi 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 440 KB 👁 1 views

The pharmacokinetics of a-dihydroergocriptine methane sulphonate in rats were investigated using an HPLC method for the detection of unchanged adihydroergocriptine (DHEK) in plasma, organs (kidneys, heart, lungs, spleen, liver, and brain), and urine. The plasma profile of DHEK obtained after intrave

The Pharmacokinetics of Butorphanol and
The Pharmacokinetics of Butorphanol and its Metabolites at Steady State Following Nasal Administration in Humans
✍ NIMISH N. VACHHARAJANI; WEN CHYI SHYU; DOUGLAS S. GREENE; RASHMI H. BARBHAIYA 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 2 views

The single-dose and steady state pharmacokinetics of butorphanol and its metabolites, hydroxybutorphanol (HO-B) and norbutorphanol (NOR-B), were studied in nine healthy male volunteers. Each subject received a single 1 mg dose of butorphanol on days 1 and 6, and a 1 mg dose every 6 h (q6h) on days 2