Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration
β Scribed by Chao Han; Paul Jung; Steven W. Sanders; Emil T. Lin; Leslie Z. Benet
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 249 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
β¦ Synopsis
Six healthy, adult male volunteers, weighing 70-90 kg, received each of two transdermal patches, applied to the chest, in a randomized crossover two-period
π SIMILAR VOLUMES
Selegiline (SEL) is a selective, irreversible inhibitor of MAO-B, used in the treatment of Parkinson's disease, either alone or as an adjunct to L-DOPA. Selegiline hydrochloride (HCl) undergoes significant first-pass metabolism following oral administration. Transdermal delivery avoids the first-pas
Stobadin dihydrochloride was administered p.0. to rats at a dose of lmg kg-' once daily for 25 consecutive days. The peak and trough concentrations of the sum of stobadin metabolites, determined from Days 6 1 6 of treatment, demonstrated a steady-state. The mean daily excretion of 'H-radioactivity d
1,2-and 1,3-glyceryl dinitrates (1,2-GDN and 1,3-GDN) are the primary metabolites of glyceryl trinitrate, a commonly used anti-anginal agent. The goal of this study was to examine the pharmacokinetic properties of these metabolites in rats. Sprague-Dawley rats were infused intravenously with 0.25 or
## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10βmg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i
Pharmacokinetic properties and tissue residues of the insecticide sulΒ―uramid (I) and its major metabolite desethylsulΒ―uramid (II) were determined in healthy sheep after bolus intravenous (IV) administration (5 and 15 mg kg Γ1 ; n = 10) and bolus intraruminal (IR) administration (100 and 400 mg kg Γ1