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Pharmacokinetics of propranolol and sotalol in hyperthyroidism

✍ Scribed by A. Aro; M. Anttila; T. Korhonen; H. Sundquist

Publisher
Springer
Year
1982
Tongue
English
Weight
621 KB
Volume
21
Category
Article
ISSN
0031-6970

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The pharmacokinetics of d-sotalol and d,
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The pharmacokinetics of d-sotalol has been studied in six healthy volunteers given single doses of 0.25, 0.50, 1, 2 mg.kg-1 i.v. and one 100 mg oral dose in comparison with the kinetics of 1 mg.kg-1 i.v. of dl-sotalol. There was no significant difference in the disposition of the d-enantiomer and th

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## Abstract We describe a thyrotoxic patient with choreic movements. The latter gradually receded and disappeared as the patient was treated with methimazole and β‐adrenoceptor blocker, and the improvement deteriorated during a β‐adrenoceptor challenge test. Our findings suggest that the pathogenes

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## Summary The perioperative course of 44 hyperthyroid patients prepared for surgery with propranolol alone, including 11 with severe thyrotoxicosis was compared to that of 20 euthyroid patients prepared for surgery with carbimazole. Conventional propranolol at a dosage of 160 mg/day was frequently