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The pharmacokinetics of d-sotalol and d,l-sotalol in healthy volunteers

✍ Scribed by J. M. Poirier; P. Jaillon; B. Lecocq; V. Lecocq; A. Ferry; G. Cheymol

Publisher: Springer
Year: 1990
Tongue: English
Weight: 376 KB
Volume: 38
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00278585

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✦ Synopsis

The pharmacokinetics of d-sotalol has been studied in six healthy volunteers given single doses of 0.25, 0.50, 1, 2 mg.kg-1 i.v. and one 100 mg oral dose in comparison with the kinetics of 1 mg.kg-1 i.v. of dl-sotalol. There was no significant difference in the disposition of the d-enantiomer and the racemate. The terminal half-life averaged 7.2 h, and the kinetics was linear, with a mean total clearance of 0.13 l.h-1.kg-1. Renal clearance of d-sotalol represented 56 to 77% of total clearance. The absolute systemic availability of oral d-sotalol was close to 100% and the elimination half-life of the oral-d-enantiomer was similar to that of the i.v. form (7.5 h).

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