Pharmacokinetics of progesterone in ovariectomized rats after single dose intravenous administration

✍ Scribed by Nutan K. Gangrade; F. Douglas Boudinot; Dr James C. Price

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 367 KB
• Volume: 13
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510130908

✦ Synopsis

The pharmacokinetics of progesterone were characterized in ovariectomized female rats. Progesterone was administered intravenously at a dose of 500 pg kg-'. Serum progesterone concentrations were determined by radioimmunoassay. Serum concentrations of progesterone were best described by a two-compartment model with elimination from the central compartment. The distribution and elimination phase half-lives were 0.13 ? 0-024 (mean 5 SD) and 1.21 k 0.21 h, respectively. Elimination of the steroid was rapid with a total clearance of 2.75k0.421 h-I kg-'. Progesterone was widely distributed in the rat with a steady state volume of distribution of 2.36kO-23 1 kg-I, a volume of the central compartment of 0-86+0.24 1 kg-' and a volume of the peripheral compartment of 1.50+0.19 1 kg-I. The results of this study suggest that the ovariectomized female rat is a suitable animal model for examining the pharmacokinetics of progesterone.