Pharmacokinetics of oral acetyl-L-carnitine in renal impairment

✍ Scribed by J. G. Kelly; S. Hunt; G. D. Doyle; M. S. Laher; M. Carmody; A. Marzo; E. Arrigoni Martelli

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 350 KB
• Volume: 38
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00315038

✦ Synopsis

Acetyl-L-carnitine 1.5 g and 3.0 g was administered as three divided doses on each of two occasions to 24 people with varying renal failure (creatinine clearance 127-8 ml.min-1). Plasma and urinary concentrations of total-L-carnitine, free (non-esterified) carnitine, short-chain esters and acetyl-L-carnitine were measured. The baseline (pre-study) concentrations of all four substances were related to renal function. Patients whose creatinine clearance was below about 30-40 ml.min-1 were had the highest concentrations. Renal elimination of all four substances was related to dose and to renal function. There was evidence for dose-related elimination, with greater elimination of the larger dose.