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Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type

โœ Scribed by L. Parnetti; A. Gaiti; P. Mecocci; D. Cadini; U. Senin

Publisher
Springer
Year
1993
Tongue
English
Weight
29 KB
Volume
44
Category
Article
ISSN
0031-6970

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โœ I. Bergman; G. Brane; C. G. Gottfries; K. -G. Jostell; I. Karlsson; L. Svennerho ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 450 KB

Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type. The drug was rapidly absorbed and an elimination half-life of 7.1 +/- 0.9 h (+/- SD, n = 8) was calculated. Plasma protein binding for alaproclate was 82 +/- 1%. Two weeks of