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Alaproclate: A pharmacokinetic and biochemical study in patients with dementia of Alzheimer type

✍ Scribed by I. Bergman; G. Brane; C. G. Gottfries; K. -G. Jostell; I. Karlsson; L. Svennerholm

Publisher: Springer
Year: 1983
Tongue: English
Weight: 450 KB
Volume: 80
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00436170

No coin nor oath required. For personal study only.

✦ Synopsis

Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type. The drug was rapidly absorbed and an elimination half-life of 7.1 +/- 0.9 h (+/- SD, n = 8) was calculated. Plasma protein binding for alaproclate was 82 +/- 1%. Two weeks of repeated administration produced plasma concentrations of alaproclate similar to those predicted from a single dose. The pharmacological effect of the drug was demonstrated by an inhibition of serotonin uptake in the patients' platelets and a reduction of the serotonin concentration in blood. Global rating of clinical efficacy showed a positive effect of alaproclate in five of the patients, mainly regarding emotional functions.

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