Pharmacokinetics of oltipraz in rat models of diabetes mellitus induced by alloxan or streptozotocin
β Scribed by Soo Kyung Bae; Ji Young Kim; Si Hyung Yang; Jin Wan Kim; Taekrho Kim; Myung Gull Lee
- Book ID
- 116718393
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 153 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0024-3205
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The pharmacokinetic and pharmacodynamic parameters of torasemide were compared after intravenous administration at a dose of 2 mg/kg to diabetic rats induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control rats. It was reported that torasemide was mainly metabolized via CYP2
## Abstract The pharmacokinetic parameters of 5βfluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control SpragueβDawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS). In DMIS rats, the area under the plasma concentrationβtime curve from