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Pharmacokinetics of morphine and its surrogates I: Comparisons of sensitive assays of morphine in biological fluids and application to morphine pharmacokinetics in the dog

✍ Scribed by Edward R. Garrett; Türkan Gürkan


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
711 KB
Volume
67
Category
Article
ISSN
0022-3549

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In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,