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Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats

โœ Scribed by John J. Kremer; Carla C. Williams; Horace D. Parkinson; Susan J. Borghoff


Book ID
119378152
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
303 KB
Volume
159
Category
Article
ISSN
0378-4274

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## Abstract Most rodent developmental toxicity studies of dibutylphthalate (DBP) have relied on bolus gavage dosing. This study characterized the developmental toxicity of dietary DBP. Pregnant CD rats were given nominal doses of 0, 100, or 500โ€‰mg DBP/kg/day in diet (actual intake 0, 112, and 582โ€‰m