Pharmacokinetics of mirtazapine in combination with amitriptyline
β Scribed by L. Mink; N. Heftink; J.G.H. Jonkman; S. Soedamah; C. Sennef
- Book ID
- 118600467
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 359 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0924-977X
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## Abstract ## Objective To assess the steadyβstate pharmacokinetics of mirtazapine (30βmg/day orally) and amitriptyline (75βmg/day orally) during combined administration compared with that of either drug administered alone. To evaluate the tolerability and effects on psychometric tests of acute a
Six healthy volunteers were given single doses of amitriptyline (AT) and of nortriptyline (NT) separated by at least 10 days. Plasma concentrations of both compounds were measured at intervals for 48 or 72 h. The total areas under the concentration-time curves for the ingested drug were greater for
Six healthy male volunteers took part in this three-period crossover study. In each session, a dose of trial drug -- either placebo, zimelidine 200 mg, or amitriptyline 75 mg -- was given at 09.00 h. Ethanol (50 g) was taken orally at 1200 h. Blood samples were taken for measurement of drug and etha