Amitriptyline pharmacokinetics a crossov
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J. E. Burch; R. P. Hullin
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Article
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1981
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Springer
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English
β 823 KB
Six healthy volunteers were given single doses of amitriptyline (AT) and of nortriptyline (NT) separated by at least 10 days. Plasma concentrations of both compounds were measured at intervals for 48 or 72 h. The total areas under the concentration-time curves for the ingested drug were greater for