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Pharmacokinetics of midazolam and alpha-hydroxy-midazolam following rectal and intravenous administration.

✍ Scribed by TG Clausen; J Wolff; PB Hansen; F Larsen; SN Rasmussen; JS Dixon; C Crevoisier

Book ID
117944537
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
652 KB
Volume
25
Category
Article
ISSN
0306-5251

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πŸ“œ SIMILAR VOLUMES

Pharmacokinetics of midazolam in childre
Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration
✍ E. Rey; L. Delaunay; G. Pons; I. Murat; M. O. Richard; C. Saint-Maurice; G. Oliv πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 294 KB

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.