A crossover study in 18 subjects evaluated the plasma concentration-time profile of two different 20 mg sustained-release (SR) methylphenidate (MPH) tablets administered before breakfast, compared to a 10 mg immediate-release (IR) tablet administered before breakfast and again 5 h later, before lunc
Pharmacokinetics of methylphenidate following two oral formulations (immediate and sustained release) in the dog
โ Scribed by M. Giorgi; U. Prise; G. Soldani; D. Neri; E. Lavy
- Publisher
- Springer Netherlands
- Year
- 2010
- Tongue
- English
- Weight
- 95 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0165-7380
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The potential advantages and disadvantages of incorporating an immediate-release (IR) component in sustained-release formulations with zero-order release characteristics (SR) are discussed. The dose of the IR component for SR doses other than the first one (DIS) should be less than that for the firs
Following oral administration of 14C labelled 8-methoxypsoralen (8-MOP) in man the plasma level course, the metabolite-patterns and the elimination of the parent compound and its metabolites have been investigated. Additionally the results discovered have been compared with the data of pharmacokinet