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The absorption of sustained-release methylphenidate formulations compared to an immediate-release formulation

✍ Scribed by Kennerly S. Patrick; Arthur B. Straughn; Eric J. Jarvi; George R. Breese; Marvin C. Meyer

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
327 KB
Volume
10
Category
Article
ISSN
0142-2782

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✦ Synopsis

A crossover study in 18 subjects evaluated the plasma concentration-time profile of two different 20 mg sustained-release (SR) methylphenidate (MPH) tablets administered before breakfast, compared to a 10 mg immediate-release (IR) tablet administered before breakfast and again 5 h later, before lunch. Plasma MPH concentrations were determined using a sensitive and precise gas chromatography-mass spectrometry method, incorporating a deuterated internal standard. The mean peak MPH concentration was 6.4ngml-' for the IR product versus 4.6ngml-' and 4.8ngml-' for the two SR formulations. Peak concentrations occurred at 3.3 h after dosing with the SR products, compared to 1.5 h after the first dose of the IR product. The extent of absorption for the three products, as determined from areas under the plasma concentration-time curves, were within 5 per cent of each other. There was no significant difference in rate or extent of absorption between the two SR formulations.

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