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Pharmacokinetics of ipriflavone and its two metabolites, M1 and M5, after the intravenous and oral administration of ipriflavone to rat model of diabetes mellitus induced by streptozotocin

โœ Scribed by Dae Y. Lee; Hye J. Chung; Young H. Choi; Unji Lee; So H. Kim; Inchul Lee; Myung G. Lee

Book ID
113592222
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
382 KB
Volume
38
Category
Article
ISSN
0928-0987

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๐Ÿ“œ SIMILAR VOLUMES

Effects of E. Coli lipopolysaccharide on
Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: Decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A2 and 2C11
โœ Hye J. Chung; Hee E. Kang; Eun J. Bae; Inchul Lee; Sang G. Kim; Myung G. Lee ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 205 KB ๐Ÿ‘ 1 views

It was reported that ipriflavone was primarily metabolized via hepatic CYP1A1/2 and 2C11 in rats. In the present study, the expression of CYP1A2 and 2C11 decreased in the liver, but increased in the intestine in rats pretreated with E. coli lipopolysaccharide (ECLPS; an animal model of inflammation)