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Pharmacokinetics of indomethacin octyl ester (prodrug) and indomethacin produced from the prodrug

โœ Scribed by Taro Ogiso; Masahiro Iwaki; Takahiro Kinoshita; Tadatoshi Tanino; Tsuyoshi Paku


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
388 KB
Volume
83
Category
Article
ISSN
0022-3549

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Carbenicillin prodrugs: Kinetics of inte
โœ Akira Tsuji; Tetsuya Terasaki; Etsuko Miyamoto; Tsukinaka Yamana ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 420 KB

The intestinal absorption of a-esters of carbenicillin disodium, carbenicillin phenyl sodium, and carbenicillin indanyl sodium was investigated using the in situ rat intestinal recirculating method. In the in situ intestinal lumen a t pH 7, two prodrugs were rapidly converted to poorly absorbable ca