Five new oligoethylene ester derivatives (9ยฑ13) of 5-iodo-2 0 -deoxyuridine (IDU) were synthesized and assayed to determine their lipophilicity by both experimental lipophilicity indices (log K 0 ) and calculated partition coefยฎcients (CLOGP). In vitro experiments were carried out to evaluate the c
Synthesis and pharmacological evaluation of oligoethylene ester derivatives as indomethacin oral prodrugs
โ Scribed by Paolo De Caprariis; Francesco Palagiano; Franco Bonina; Lucia Montenegro; Michele D'Amico; Francesco Rossi
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 474 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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## Abstract A novel series of iodinated indomethacin derivatives was synthesized, and evaluated as selective inhibitors of COXโ2. Two candidate compounds __N__โ(__p__โiodobenzyl)โ2โ(1โ(__p__โchlorobenzoyl)โ5โmethoxyโ2โmethylโ1__H__โindolโ3โyl)acetamide (3) and 1โ(__p__โiodobenzyl)โ5โmethoxyโ2โmethy
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