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Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin

✍ Scribed by Vermorken, Jan B; Vijgh, Wim J F Van Der; Gall, Ina Klein, Helen E; Groeningen, Cees J Van; Hart, Guus A M; Pinedo, Herbert M


Book ID
109843997
Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
749 KB
Volume
39
Category
Article
ISSN
0009-9236

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PHARMACOKINETICS OF ELEMENTAL PLATINUM (
✍ WILLIAM D. FIGG; MICHAELE C. CHRISTIAN; RICHARD LUSH; CHARLES J. LINK; PATRICIA πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 185 KB

Preclinical data suggest that ormaplatin (tetrachloro-(d1-trans)-1, 2-diamminocyclohexaneplatinum) has substantial activity in cisplatin-resistant tumor models and may be less nephrotoxic than cisplatin. Based on these data we initiated a phase I clinical trial in patients with refractory metastatic