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Pharmacokinetics of continuous-infusion amsacrine and teniposide for the treatment of relapsed childhood acute nonlymphocytic leukemia

โœ Scribed by William P. Petros; John H. Rodman; Joseph Mirro; William E. Evans


Publisher
Springer
Year
1991
Tongue
English
Weight
416 KB
Volume
27
Category
Article
ISSN
0344-5704

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Background. The outcome of patients with acute myeloid leukemia (AML) who relapse or fail to achieve an initial remission has been dismal. Procedure. Fifteen pediatric patients with AML, 4 relapsed and 11 primary refractory, were reinduced with a loading bolus of 0.5 g/m 2 cytarabine (ara-C) followe