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Pharmacokinetics of chronically administered all-trans-retinoyl-β-glucuronide in mice

✍ Scribed by Neil Sidell; Sayan Sawatsri; Michael J. Connor; Arun B. Barua; James A. Olson; Randal K. Wada


Book ID
117617748
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
462 KB
Volume
1502
Category
Article
ISSN
0925-4439

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All-trans-retinoyl-b-D-glucuronide (RAG) is an endogenous active metabolite of all-trans-retinoic acid (ATRA). In the present study, the pharmacokinetics of RAG was examined after the administration of a single intravenous does (5, 10, or 15 mmol/kg) and of multiple daily intravenous doses (5 mmol/k

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All-trans-retinoyl-beta-D-glucuronide (all-trans-RAG) is a water-soluble derivative of all-trans-retinoic acid (all-trans-RA) and has been characterized as an endogenous metabolite of vitamin A in rat bile and kidney. All-trans-RAG was previously demonstrated to be a major metabolite after applicati