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Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats

✍ Scribed by Jung, Ji Won; Kim, Ju Myung; Jeong, Jin Seok; Son, Miwon; Lee, Hye Suk; Lee, Myung Gull; Kang, Hee Eun


Book ID
126686002
Publisher
Informa plc
Year
2014
Tongue
English
Weight
318 KB
Volume
44
Category
Article
ISSN
0049-8254

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Possible factor for nonlinear pharmacoki
✍ Yoshihiko Tagawa; Kiyoshi Miwa; Kenji Yamashita; Ryoichi Tsukuda; Yoshinobu Yosh πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 158 KB

A new antirheumatic, TAK-603, shows nonlinear pharmacokinetics in both animals and humans. To elucidate the mechanism of these nonlinear pharmacokinetics, in vivo and in vitro metabolism of 14 C-labeled TAK-603 ([ 14 C]TAK-603) was studied using rats as these resemble humans in their metabolic profi