Pharmacokinetics of amphotericin B colloidal dispersion in liver failure
β Scribed by Stefan Weiler; Rosa Bellmann-Weiler; Michael Joannidis; Romuald Bellmann
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 70 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
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π SIMILAR VOLUMES
The hepatic distribution, biliary excretion, and mass balance of liposomal amphotericin B (L-AmB) were investigated in recirculated isolated perfused rat liver. The results were compared with those from the conventional AmB formulation, amphotericin B deoxycholate (D-AmB). L-AmB was introduced as a
## Abstract Amphotericin B (AmB) is widely used for the treatment of systemic mycoses. The current therapeutic regimens for this drug are complex and somewhat empirical, in part because of very limited information about the disposition kinetics of this agent. In this study, we examined the disposit