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Pharmacokinetics of alkylating metabolites of cyclophosphamide in different strains of mice

✍ Scribed by A.L. Pukhalsky; A.P. Toptygina; V.V. Viktorov


Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
390 KB
Volume
12
Category
Article
ISSN
0192-0561

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Pharmacokinetics of (R)- and (S)-cycloph
✍ Marion L. Williams; Irving W. Wainer; Camille P. Granvil; Barbel Gehrcke; Mark L πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 207 KB

The complete pharmacokinetics (PK) of (R)-and (S)-cyclophosphamide (CP) and their dechloroethylated (DCE) metabolites have not been reported to date. We collected plasma and urine samples from 12 cancer patients and determined concentrations of both enantiomers of CP and DCE-CP using a chiral GC-MS