Lymphocyte deactivation by (potential immunosuppressant) alkylating metabolites of cyclophosphamide
✍ Scribed by Michael W. Whitehouse; Frances W. J. Beck; Marlies M. Dröge; Robert F. Struck
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1974
- Tongue
- English
- Weight
- 597 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1420-908X
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📜 SIMILAR VOLUMES
We have evaluated the immunosuppressive effect of a new stable derivative of cyclophosphamide (ASTA Z 7557) on human lymphocyte immunoglobulin biosynthesis in vitro. When graded amounts of the drug are added to lymphocyte cultures stimulated with the helper T cell-dependent activator (PWM), a marked
## Abstract The phenotypes of the affector and effector cell populations involved during the induction of permanent tumor regression by combined therapy using cyclophosphamide (CY) and immune spleen cells were identified. Permanent tumor regression was dependent on the presence of Thy‐1^+^ Lyt‐2^+^