## Abstract The pharmacokinetics and pharmacodynamics of bumetanide were investigated after intravenous (i.v.) administration, 10 mg kg^β1^, and oral administration, 20 mg kg^β1^, to spontaneously hypertensive rats (SHRs) and deoxycorticosterone acetateβsalt induced hypertensive rats (DOCAβsalt rat
Pharmacokinetics of acetaminophen after intravenous and oral administration to spontaneously hypertensive rats and normotensive wistar rats
β Scribed by Seong H. Jang; Min H. Lee; Myung G. Lee
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 614 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The purpose of this study was to investigate the causes for the differences observed in the pharmacokinetics of YJAβ20379β8 in 16βweekβold spontaneously hypertensive rats (SHRs). To see if the hereditary characteristics of SHRs was the cause, 20 mg/kg of the drug was intravenously infus
The pharmacokinetics of the anticholinergic drug ethopropazine (ET) have been studied in the rat after intravenous (i.v.) and oral administration. After i.v. doses of 5 and 10 mg/kg ET HCl, mean +/- S.D. plasma AUC were 9836 +/- 2129 (n = 4 rats) and 13096 +/- 4186 ng h/mL (n = 5 rats), respectively