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Pharmacokinetics of a Single Intravenous and Oral Dose of Pafenolol—a Beta1Adrenoceptor Antagonist with Atypical Absorption and Disposition Properties—in Man

✍ Scribed by Carl G. Regårdh; Per Lundborg; Margareth Gabrielsson; Asger Heggelund; Kerstin Kylberg-Hanssen

Book ID
110343518
Publisher
Springer US
Year
1990
Tongue
English
Weight
874 KB
Volume
07
Category
Article
ISSN
0724-8741

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📜 SIMILAR VOLUMES

Pharmacokinetics of pafenolol in the rat
Pharmacokinetics of pafenolol in the rat: A suitable model for studying absorption mechanisms of a drug exhibiting unusual absorption properties in man
✍ Hans Lenneras; Carl G. Regårdh 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 559 KB

The pharmacokinetics of pafenolol, a highly selective /?,-adrenoceptor antagonist, have been studied in starved and unstarved rats. Separate groups received intravenous doses (0.3 and 3.0pmol kg-I) and oral doses (1 and 25pmol kg-I). The systemic clearance of pafenolol was constant in the dose range