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Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in Rats

✍ Scribed by Jennifer D. Wright; Tianwei Ma; Chung K. Chu; F. Douglas Boudinot


Book ID
110346518
Publisher
Springer US
Year
1995
Tongue
English
Weight
652 KB
Volume
12
Category
Article
ISSN
0724-8741

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DISCONTINUOUS ORAL ABSORPTION PHARMACOKI
✍ Jennifer D. Wright; Tianwei Ma; Chung K. Chu; F. Douglas Boudinot 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 595 KB

## 1-(2-fluoro-5-methyl-&L-arabinofuranosyl)uracil (L-FMAU) , the L isomer of FMAU, has shown potent activity against hepatitis B virus and Epstein-Barr virus. L-FMAU showed double peaks in the plasma concentration versus time profiles following oral administration to rats, indicating discontinuous