## Abstract The pharmacokinetics of HIโ6 were studied following intravenous administration to beagle dogs (__n__ = 7). The bioavailability of two different strength intramuscularly administered doses was also determined in the same animals. After a 20 mg kg^โ1^ intravenous dose, the mean (ยฑS.D.) in
Pharmacokinetics and pharmacodynamics of the oxime HI6 in dogs
โ Scribed by R. Klimmek; P. Eyer
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 631 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0340-5761
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In a double-blind, placebo-controlled, single-dose ascending pharmacokinetics and tolerance study, we evaluated the bispyridinium oxime HI-6 dichloride monohydrate (62.5, 125, 250, and 500mg), administered intramuscularly with atropine sulphate, 2 mg, in 24 healthy male volunteers. The plasma HI-6 p
HI 6(pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]-2- [(hydroxyimino)methyl]-dichloride belongs to a series of bisquaternary pyridinium oximes that are effective against poisoning with extremely toxic organophosphates. Since HI 6 has been shown to be unstable at pH 7.4 and to release signific