𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs

✍ Scribed by Sylvie Giasson; Denis Garceau; Walid Homsy; Louis Dumont


Publisher
Springer US
Year
1995
Tongue
English
Weight
828 KB
Volume
9
Category
Article
ISSN
0920-3206

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Pharmacokinetics of multiparticulate sus
✍ Kazuo Murata; Kazuo Noda πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 379 KB πŸ‘ 1 views

The in vivo performance of multiparticulate sustained-release diltiazem preparations [HER-SR(A,B,C)] coated with water-insoluble polymer (ethylcellulose), to control the in vitro dissolution rate, was evaluated in dogs. With a decrease in dissolution rate, HER-SR maintained sustained-release charact

Comparative pharmacokinetics and pharmac
✍ Sonia Guimont; Dr HΓ©lΓ¨ne Landriault; Keith Klischer; Michael Grace; Chantal Lamb πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 586 KB

CardizemOSR and Bi-TildiemO were both approved in their respective countries on the basis of clinical trials demonstrating efficacy and safety in the treatment of angina pectoris. In this cross-over randomized study, we assessed whether these two sustained-release formulations of diltiazem have equi

Relationship between the cardiovascular
✍ VilliΓ¨re ValΓ©rie; Dumont Louis; Lefebvre Marc; Garceau Denis; Chartrand Claude; πŸ“‚ Article πŸ“… 1991 πŸ› Springer US 🌐 English βš– 524 KB

We evaluated the relationship between the cardiovascular effects of clentiazem (TA-3090), a new 1,5-benzothiazepine calcium antagonist with high lipophilicity, and both its plasma and myocardial concentrations. Anesthetized, open-chest dogs, instrumented for hemodynamic data recording and blood samp

The effect of multiple doses of ranitidi
✍ Pollen K. F. Yeung; Susan J. Mosher; HΓ©lΓ¨ne Landriault πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 465 KB πŸ‘ 2 views

## Abstract In order to determine the potential pharmacokinetic drug interaction between ranitidine and diltiazem (DTZ), each of ten male beagle dogs, age 2Β·7–4Β·0 years, weight 13–16 kg, received a single oral dose of sustained release DTZ with and without previous multiple oral doses of ranitidine