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PHARMACOKINETICS AND PHARMACODYNAMICS OF INDOMETHACIN: EFFECTS ON CEREBRAL BLOOD FLOW IN ANAESTHETIZED SHEEP

✍ Scribed by Richard N Upton; Mads Rasmussen; Cliff Grant; Allison M Martinez; Georg E Cold; Guy L Ludbrook

Book ID
108940186
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
128 KB
Volume
35
Category
Article
ISSN
0305-1870

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## Abstract The work presented here uses combined blood oxygenation level‐dependent (BOLD) and arterial spin tagging (AST) approaches to study the effect of indomethacin on cerebral blood flow (CBF) and oxygen consumption (CMRO~2~) increases during motor activation. While indomethacin reduced the C