Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: A comparison with atenolol
β Scribed by I. Blomqvist; G. Westergren; A. Sandberg; U. E. Jonsson; P. Lundborg
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 631 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0031-6970
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We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with those of a conventional combination tablet. The controlled-release formulation gave less vari
In a double-blind, randomised, cross-over study, the pharmacokinetic/dynamic effects and subjective symptoms of a new controlled-release (CR) formulation of metoprolol (50 and 100 mg) have been compared with atenolol (50 mg) and placebo in 20 elderly healthy subjects. The metoprolol CR formulation d