A single and multiple dose pharmacokinetic and pharmacodynamic comparison of conventional and slow-release metoprolol
β Scribed by M. J. Kendall; V. A. John; C. P. Quarterman; P. G. Welling
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 663 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
Diltiazem is a calcium antagonist used in angina pectoris and hypertension. There is little information concerning the slow-release (SR) formulation in the literature. The pharmacokinetics of diltiazem SR (120 mg) have been assessed over a 36 h period in healthy volunteers after single-(SD) and mult
We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with those of a conventional combination tablet. The controlled-release formulation gave less vari