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Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

✍ Scribed by Shih-Ming Chen; Mei-Yu Fan; Chia-Chi Tseng; Yih Ho; Kuang-Yang Hsu

Book ID
116921788
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
333 KB
Volume
50
Category
Article
ISSN
0041-0101

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## Abstract Ingestion of aristolochic acids (AA) contained in herbal remedies results in aristolochic acid nephropathy (AAN), which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA I and AA II, primary components in AA, have similar genotoxic potentia