Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration
β Scribed by Shri N. Giri; Qingjian Wang; Yan Xie; Jozsef Lango; Dexter Morin; Solomon B. Margolin; Alan R. Buckpitt
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 161 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.311
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Recombinant tissue-type plasminogen activator (rt-PA) is indicated for the treatment of acute myocardial infarction as a dose of up to 100 mg. Several clinical trials have suggested that higher patency rates can be achieved with a rapid drug administration. A study was conducted in rabbits to determ
HEPP (D, L-3-hydroxy-3-ethyl-3-phenylpropanamide) is a novel compound with a wide spectrum of anticonvulsant activity and relatively low toxicity. The aim of this investigation was to study the pharmacokinetics of HEPP in mongrel dogs and to assess its linearity after intravenous administration of 8
The pharmacokinetics of SDZ 64412, an antiasthmatic agent, were investigated following intravenous, oral, and inhalation dosing in rats. 14C-SDZ 64-412 was administered intravenously (2.75 mg kg-') and orally (5.5 mg kg-', 110 mg kg-I), whereas nohradiolabeled drug (5.04 mg kg-') was-administered us