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Pharmacokinetics and biotransformation of benzbromarone in man

โœ Scribed by H. Ferber; H. Vergin; G. Hitzenberger


Publisher
Springer
Year
1981
Tongue
English
Weight
472 KB
Volume
19
Category
Article
ISSN
0031-6970

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Following oral administration of the uricosuric drug benzbromarone two major metabolites appear in the circulation. 1'-hydroxy-benzbromarone (M1), and a second product (M2) of unknown structure. The plasma concentrations of the parent drug and of M1 and M2 have now been compared in two different eli

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The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an a