Metabolism of benzbromarone in man
β Scribed by J. Broekhuysen; M. Pacco; R. Sion; L. Demeulenaere; M. Hee
- Publisher
- Springer
- Year
- 1972
- Tongue
- English
- Weight
- 649 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
Following oral administration of the uricosuric drug benzbromarone two major metabolites appear in the circulation. 1'-hydroxy-benzbromarone (M1), and a second product (M2) of unknown structure. The plasma concentrations of the parent drug and of M1 and M2 have now been compared in two different eli
The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an a
To determine the elimination phenotype of the uricosuric agent benzbromarone 100 mg of the drug was administered as a single oral dose to 11 volunteers on a formula diet; plasma concentration-time profiles of the parent drug and the main metabolites M 1 (l'-hydroxybenzbromarone) and M 2 (6-hydroxy-b