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Pharmacokinetics and Bioavailability of Tacrolimus in Rats with Experimental Renal Dysfunction

✍ Scribed by HIROMI OKABE; YUKIYA HASHIMOTO; KEN-ICHI INUI

Book ID
111768594
Publisher
Pharmaceutical Press
Year
2000
Tongue
English
Weight
77 KB
Volume
52
Category
Article
ISSN
2042-7158

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In a pharmacokinetic study, 15, 30, 60, and 150 mg kg-' intravenous and oral doses of methocarbamol were administered to rats. Differences observed in plasma clearance values, i.e. 0~0203,0~0156,0~0123, and 0-0085 1 kg-' min-' for 15,30,60, and 150 mg kg-', respectively, suggested a dosedependent ph