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Pharmacokinetics and bioavailability of dapsone in the beagle dog

โœ Scribed by P. Hekman; P. van Rens; E. C. Rietvel; A. Coert

Book ID
114873538
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
321 KB
Volume
30
Category
Article
ISSN
0022-4510

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The absorption and disposition kinetics of HI-6 were determined in Beagle dogs given single doses (25 mg kg-') of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC. A twocompartment open model was used to describe the d