N-pentyl-sparsomycin (PSm) is a lipophilic analogue of sparsomycin (Sm), which is a well known inhibitor of protein synthesis. This compound was selected for preclinical pharmacokinetic studies because of its high in vitro and in vivo antitumor activity. In this study in which the drug was evaluated
Pharmacokinetics and toxicology of sparsomycin in beagle dogs
โ Scribed by Zbigniew Zylicz; D. J. Theo Wagener; Pilar Fernandez Moral; Helga Rennes; Johannes M. C. Wessels; Benjamin Winograd; Eppo Kleijn; Tom B. Vree; Urbanus Haelst; Leon A. G. M. Broek; Harry C. J. Ottenheijm
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 939 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
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## Abstract The pharmacokinetics of HIโ6 were studied following intravenous administration to beagle dogs (__n__ = 7). The bioavailability of two different strength intramuscularly administered doses was also determined in the same animals. After a 20 mg kg^โ1^ intravenous dose, the mean (ยฑS.D.) in
We have developed a beagle dog model to study the pharmacology and toxicology of anticancer drugs administered through the 3rd or lateral ventricles. A Foltz-type reservoir was implanted SC and connected by tube into a cerebral ventricle. Drugs were administered directly into the reservoir; CSF samp