Pharmacokinetics and antitumor activity of a new platinum compound,cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl- 1, 3-dioxolane]platinum(II), as determined by ex vivo pharmacodynamics

Synthesis of carbon-14 labelled cis-malo

Synthesis of carbon-14 labelled cis-malonato [(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane] platinum(II) (ski 2053R)

✍ Dae-Kee Kim; Youngseok Kim; Jonggill Rim; Ganghyeok Kim; Jongsik Gam; Sungkun So 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 448 KB

## Abstract The synthesis of ^14^C‐labelled __cis__‐malonato[(4__R__,5__R__)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐^14^C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5