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Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats

✍ Scribed by Ashraf Yassen; Erik Olofsen; Jingmin Kan; Albert Dahan; Meindert Danhof

Publisher
Springer US
Year
2007
Tongue
English
Weight
430 KB
Volume
25
Category
Article
ISSN
0724-8741

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A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of gemifloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of gemifloxacin at a rate of 4 mg kg of body weight