A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of gemifloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of gemifloxacin at a rate of 4 mg kg of body weight
Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats
✍ Scribed by Zhenling Yao; Debra C. DuBois; Richard R. Almon; William J. Jusko
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 191 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0022-3549
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